Based on my time with the game so far, I definitely agree with points two and three on Sampo's list (unlock upgrades and install enhancements before each run). The game is a little bit different kind of difficulty compared to other twin-stick shooters. Engaging in firefights with a group of enemies is a quick way to get yourself killed. You're usually better off surprising them and picking a couple off before they can even shoot at you, or using the environment to block their fire so you can gain some distance and take on just a couple at a time.

While your goal is the same each time (i.e., kill the Overseer), your path there will be different. Neon Chrome utilizes some roguelike elements, such as procedurally generated levels and different purchasable perks, to ensure a different experience each time through although some things, like boss battles, will be more fixed. You'll also be able to shoot through walls and other environmental structures so you can get the drop on enemies or make a quick getaway.